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October 18, 1952


JAMA. 1952;150(7):711. doi:10.1001/jama.1952.03680070081026

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Intradermal Administration of Corticotropin.  —R. Debré and P. Mozziconnacci, and their associates at the Clinic of the Hospital for Sick Children, gave six guinea pigs, six rabbits, six white rats, and six mice progressive concentrations of corticotropin (ACTH) by intradermal route, so that for a week the animals received five to six injections of.2 cc., which corresponds to 1.2 to 4 mg. After having ascertained the absolute innocuousness in animals, the authors performed trials in children, using a solution of.1 cc., which corresponds to 2 mg. of corticotropin. They injected.2 cc. per intradermal "pimple," giving from one to five injections according to the dose, which usually ranged from 8 to 12 mg. per 24 hours. The injection was performed on the anterior face of the thigh; it was less painful than with intramuscular administration. The authors found that with doses of hormones three times smaller they obtained a fall of

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