• The evaluation of any drug used to treat the comcon cold must necessarily be based on clinical observations. Bioflavonoids and ascorbic acid, singly and in combination, were evaluated in a study on almost 2,000 persons as to their efficacy, not by symptom alleviation but as to whether it would shorten the course of illness. The overwhelming impression gained from the study presented is the singular lack of effect in altering the course of the common cold by either the bioflavonoid or the ascorbic acid.
Tebrock HE, Arminio JJ, Johnston JH. USEFULNESS OF BIOFLAVONOIDS AND ASCORBIC ACID IN TREATMENT OF COMMON COLD. JAMA. 1956;162(13):1227–1233. doi:10.1001/jama.1956.02970300027010
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