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May 19, 1956

UNIQUE ALLERGIC RESPONSE TO SULFISOXAZOLE (GANTRISIN)REPORT OF A CASE

JAMA. 1956;161(3):228. doi:10.1001/jama.1956.62970030011009d
Abstract

Undesirable side-effects from sulfisoxazole (Gantrisin) therapy occur in less than 0.1% of cases according to Yow's1 recent study on 1,000 consecutive patients; yet, there have been occasional reports in the literature concerning untoward toxic reactions of sulfisoxazole. These have included maculopapular rash, urticaria, anorexia, nausea, vomiting, headache and vertigo,2 leukopenia,3 agranulocytosis,4 hematuria,5 hypoprothrombinemia,6 petechial hemorrhages,7 and vesicles and bullae in localized areas.8 The purpose of this study is to report a severe and unique allergic response to sulfisoxazole.

On April 26, 1954, a 77-year-old female sustained a fall, injuring her left shoulder and hip. She was admitted to the orthopedic service of St. Francis Hospital, Evanston, Ill., where x-rays revealed a fracture of the surgical neck of the left humerus and an intertrochanteric fracture of the left femur without displacement. The patient's general condition on admission was good. The blood pressure was

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