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December 8, 1956


JAMA. 1956;162(15):1382-1387. doi:10.1001/jama.1956.72970320004009

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Means for controlling the excessive generalized vasospasm found in patients with chronic arterial hypertension have greatly improved during the past 5 years. The development of new drugs with specific actions has pointed up the several mechanisms that act together to cause vasospasm; it has resulted in alterations toward or to normal of a disturbed physiological and biochemical state and has effected considerable reduction in morbidity and mortality and sometimes remarkable clinical improvement in patients suffering from fatal forms of the disease. Furthermore, the question of what is cause and what is effect has been clarified. The results in well-treated patients, formerly suffering from hypertension of severe degrees and often with serious secondary conditions, may be summarized as follows: a virtual disappearance of congestive heart failure, formerly the major cause of death; considerable reduction in incidence of cerebral vascular accidents, especially hemorrhage; slowing, halting, or even regression of progressive renal functional

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