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May 19, 1956

Biochemical Mechanisms in Inflammation

JAMA. 1956;161(3):292. doi:10.1001/jama.1956.02970030110034

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This monograph, published six years after the first edition, presents a description of the cytological and chemical changes that occur in inflammation, including the appearance of factors that are believed to be specific mediators of the pathological changes. There are chapters on the role of inflammation in immunity, diabetes in inflammation, repair, and the anti-inflammatory problem. The material presented in this volume is based on observations of the author and of others in this field for more than 20 years. Despite the author's evidence for his belief that the mediators of increased capillary permeability, migration of leukocytes, leukocytosis, leukopenia, and fever are chemically distinct products of injured cells, his thesis remains far from proved, as he himself admits in the preface. The difficulty in reproducing his observations in several other laboratories has limited acceptance of his premises. This volume is a vigorous presentation of one person's point of view and

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