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November 8, 1952

Vitamins and Hormones: Advances in Research and Applications. Volume IX.

JAMA. 1952;150(10):1055-1056. doi:10.1001/jama.1952.03680100097042

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These volumes, issued annually, attempt to review recent progress in vitamin and endocrine research. In the present volume there is much to interest the biochemist and specialist in metabolism in the discussions of vitamin B12, biotin, other B vitamins, and antimetabolites of nucleic acid, as well as the effect of vitamin deficiencies on the adrenocortical system and of estrogens on enzyme activity. For endocrinologists and gynecologists, the section on synthesis and metabolism of radioactively-labeled steroids describing their localization in man and excretion routes and metabolites, while interesting, is marred by the fact that in most cases the steroids were tagged with radioactive halogens, sodium, or sulfur rather than carbon 14. Whenever the carbon-14-tagged diethylstilbestrol was compared with estrogens not so tagged, it failed to disclose similar localization patterns. This dissimilarity may have been due to the fact that the sulfate radical or the tagged halogen was being followed in

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