It is well known that desoxycorticosterone acetate causes a retention of sodium and loss of potassium in both man and experimental animals. But it is not clear whether the potassium deficiency as such can lead to a retention of sodium or whether the sodium retention causes a wasting of potassium. In Addison's disease, in which there is a lack of desoxycorticosterone acetate-like hormone, the serum sodium level falls before an increase in the potassium level occurs.1
Recently Fourman and associates2 studied intensively the changes occurring in the urine and blood electrolytes following administration to a normal subject of desoxycorticosterone acetate. During the test periods, and also during the two control periods, the subject was maintained on a daily intake of 3,000 ml. of water containing 51 mEq. of sodium chloride, 13.4 mEq. of potassium chloride, and 500 gm. of glucose, given in divided doses at two hour intervals
DESOXYCORTICOSTERONE ACETATE AND ELECTROLYTE METABOLISM. JAMA. 1952;150(12):1223. doi:10.1001/jama.1952.03680120059015
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