• Several lots of poliomyelitis vaccine were used in a study of the serologic responses of 251 children to intramuscular inoculation. The children, whose ages ranged from 2 months to 5 years, were divided into five groups so that several types and schedules of vaccination could be tried. The response was assessed by means of a virus neutralization test that measured the ability of the patient's serum, when mixed with virus, to prevent infection of a tissue culture by the virus. Three types of virus were used in this test.
The resulting titers indicated that in general a single injection of vaccine did not evoke a demonstrable increase of neutralizing antibodies but that two injections did. Children receiving three injections responded with increased neutralizing antibodies for all three types of virus. In four groups, secondary inoculations were tried six months later and had a marked effect in increasing the antibody titer. Both infants and preschool children responded well to these vaccinations.
Brown GC, Smith DC. SEROLOGIC RESPONSE OF INFANTS AND PRESCHOOL CHILDREN TO POLIOMYELITIS VACCINE. JAMA. 1956;161(5):399–403. doi:10.1001/jama.1956.02970050001001
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