• Cortisone in dosage of 50 mg. every six hours for a total of 400 mg. was given orally to 50 patients after pneumoencephalography; 47 similar patients received a placebo. The two groups were then compared as to the incidence, severity, and duration of headache following this procedure.
The patients who received cortisone did better than the contratest group, and the difference was statistically significant in patients whose symptoms had an organic rather than psychogenic basis.
Patients who received 70 to 150 cc. of air (or oxygen) suffered as severely on the first day as did those who received 155 to 315 cc., but the relief afforded by cortisone was more striking in those who received the larger volume of gas.
Fly OA, MacCarty CS, Gage RP, MacKinnon HN, Jones PH. A CONTROLLED STUDY OF CORTISONE THERAPY FOR HEADACHE AFTER PNEUMOENCEPHALOGRAPHY. JAMA. 1956;161(5):415–418. doi:10.1001/jama.1956.02970050017004
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