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December 13, 1952


JAMA. 1952;150(15):1480-1482. doi:10.1001/jama.1952.03680150034008

Allergic therapy, in my opinion, has been greatly hampered by the reluctance of many to acknowledge the theory of infective allergy. Indeed, allergists other than Cooke and his followers still fail to regard foci of infection as specific etiological factors. The practicing physician, however, recognizes the significance of focal infection because he sees the therapeutic results obtained when the chronic foci are removed. It is hoped that more and more physicians will recognize the necessity of the removal of foci in treatment, as they begin to understand the importance of bacterial sensitivity in allergy.

But before one can discuss intelligently the importance of focal infections in allergy, it is first necessary to consider the theoretical basis on which the concept of bacterial hypersensitivity rests. In 1921, Zinsser produced proof that the anaphylactic and tuberculin types of sensitization could exist in the same animal separately or at the same time. Rich

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