• The flow of perfusion fluid through isolated rabbit kidneys was greatly accelerated by the vasodilating action of papaverine. Similar results were obtained when human kidneys were perfused promptly post mortem. In the untreated kidney, intense vasoconstriction so narrowed the blood vessels that the formed elements of the blood could not pass through. This suggested the theory that anuria before death is caused by renal ischemia and should be correctible by the vasodilating action of papaverine.
Eleven patients suffering with acute renal failure were given papaverine. Ten responded promptly with material increases in urinary output. In the average patient, the recommended dosage on the basis of this experience is 0.5 grain (32 mg.) of papaverine hydrochloride injected intramuscularly every 2 hours for 48 hours as an addition to the standard therapy.
Johnstone PN, Stone RG, Burdick HC, et al. STUDIES ON THE ETIOLOGY AND TREATMENT OF ACUTE RENAL FAILURE. JAMA. 1956;161(6):491–494. doi:10.1001/jama.1956.02970060005002
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