The frequent appearance of neoplasms in rats following prolonged administration of pituitary growth hormone1 has led Moon and his associates to investigate the possible significance of pituitary function in neoplastic disease. In their initial experiments2 the University of California workers gave 15 adult female rats intraperitoneal injections of pure pituitary growth hormone six days a week for approximately one year. Fifteen rats treated with human serum albumin served as controls. At autopsy, lymphosarcomas were present in the lungs of six of the animals receiving pituitary growth hormone. These neoplasms apparently arose from the peribronchial lymphoid tissue, which was hyperplastic in all 15 experimental animals. The adrenal medullas were also hyperplastic in all animals receiving hormone injections, and in 9 animals there were nodular areas of atypical medullary cells, interpreted as early neoplastic lesions, which in some instances had invaded the adrenal cortex. In six of the animals, the
CARCINOGENESIS AND THE PITUITARY GLAND. JAMA. 1952;150(16):1604. doi:10.1001/jama.1952.03680160054016
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