• Jaundice in four patients who had received chlorpromazine was observed under conditions that afforded a unique opportunity for the study of hepatic alterations. In one, a biopsy was done. In the other three, autopsies were performed after death from other causes. The hepatic tissues formed a series manifesting chlorpromazine jaundice in various stages of its development and recession.
During the jaundice there was intrahepatic canalicular obstruction indistinguishable from other types of obstructive jaundice except those in which the larger bile ducts were markedly involved, usually as a result of extrahepatic duct obstruction. After recession of the jaundice the liver tissues apparently returned to normal without residual evidence of injury.
The findings suggested the likelihood that chlorpromazine caused an increased viscosity of the bile leading to stasis in the smaller bile passages.
Stein AA, Wright AW. HEPATIC PATHOLOGY IN JAUNDICE DUE TO CHLORPROMAZINE. JAMA. 1956;161(6):508–511. doi:10.1001/jama.1956.02970060022006
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