• Pinworm infestation in 60 patients was treated with piperazine citrate by mouth in a seven-day course. No advantages were seen in prolonging the treatment to 10 or 14 days, in dividing the daily dose, or in substituting piperazine phosphate or calcium dipiperazine dicitrate.
Ascariasis in 46 patients was treated with a single dose of piperazine citrate, and 34 were cured by this one-day treatment. A two-day treatment cured 50 out of 53 patients. The timing of the dose, whether before or after breakfast, had no discernible influence on the result.
Side-reactions in the form of urticaria, nausea, or diarrhea were seen but rarely in 400 patients who received the recommended dosage of 50 to 75 mg. of piperazine (calculated as the hexahydrate) per kilogram of body weight per day.
Brown HW, Chan K, Hussey KL. TREATMENT OF ENTEROBIASIS AND ASCARIASIS WITH PIPERAZINE. JAMA. 1956;161(6):515–520. doi:10.1001/jama.1956.02970060029008
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