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December 27, 1952


Author Affiliations

Galveston, Texas
From the Department of Internal Medicine, University of Texas, Medical Branch.

JAMA. 1952;150(17):1655-1660. doi:10.1001/jama.1952.03680170009003

The purpose of this discussion is to examine, from a critical point of view, the concepts of the causes of peptic ulcer as they are currently understood, to consider the defects in the methods employed for ulcer control, and to inquire into what may be done in order that the generally unsatisfactory status of the management of the disease may be improved. The present generation of physicians has witnessed greater advances in medicine than have occurred in any previous corresponding period, but few, indeed, are the really significant additions to the knowledge of peptic ulcer. Those that have been made have altered but slightly the basic understanding and treatment of the disease, this despite an enormous amount of effort directed toward the solution of the problem at both the experimental and clinical levels.

CAUSE OF PEPTIC ULCER  Outstanding among the obstacles to progress in treatment of ulcer is the incomplete