It is a common clinical experience that the currently available insulin preparations with protracted action, if given in one daily injection, are incapable of providing satisfactory regulation of the blood sugar level in a considerable number of patients with difficult cases of diabetes.1 One injection daily, which is desired by diabetics and physicians, requires adequate timing of the preparation in use. Our clinical investigations on the new zinc insulin preparations, which were described in an earlier paper,2 were carried out to determine the correct timing for these drugs. The results we have attained up to the present throw some light on the problem and indicate that these zinc insulin preparations may offer a solution to the problem of providing a single daily injection for such patients. These preparations are based on the recent discovery that insulin alone, in a precipitated amorphous or crystalline state, together with a small
Hallas-Møller K, Jersild M, Petersen K, Schlichtkrull J. ZINC INSULIN PREPARATIONS FOR SINGLE DAILY INJECTION: CLINICAL STUDIES OF NEW PREPARATIONS WITH PROLONGED ACTION. JAMA. 1952;150(17):1667–1671. doi:10.1001/jama.1952.03680170021006
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