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Article
June 16, 1956

EVALUATION OF THE SERUM GLUTAMIC OXALACETIC AMINOPHERASE (TRANSAMINASE) TEST: ITS USE IN DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION

Author Affiliations

Los Angeles

From the Los Angeles County Hospital services of the departments of medicine of the University of Southern California and the College of Medical Evangelists (Drs. Denney, McAuley, Martin, and Ware) and the Bioscience Laboratories (Dr. Segalove).

JAMA. 1956;161(7):614-616. doi:10.1001/jama.1956.02970070046012
Abstract

• Serum aminopherase levels were determined in 77 patients with the unequivocal diagnosis of myocardial infarction and were compared with the levels found in 73 patients with other diseases. A strong association was found between myocardial infarction and high serum aminopherase levels.

The occasional finding of a low aminopherase level in the undeniable presence of myocardial infarction (false negative) was explained by the occasionally transient nature of the elevation; the danger of confusion can be reduced by sufficiently prompt and frequent determinations. The finding of a high aminopherase level in the absence of myocardial infarction (false positive) was also observed, especially in disease of the pancreas and liver.

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