• Serum aminopherase levels were determined in 77 patients with the unequivocal diagnosis of myocardial infarction and were compared with the levels found in 73 patients with other diseases. A strong association was found between myocardial infarction and high serum aminopherase levels.
The occasional finding of a low aminopherase level in the undeniable presence of myocardial infarction (false negative) was explained by the occasionally transient nature of the elevation; the danger of confusion can be reduced by sufficiently prompt and frequent determinations. The finding of a high aminopherase level in the absence of myocardial infarction (false positive) was also observed, especially in disease of the pancreas and liver.
Denney JL, McAuley CB, Martin HE, Segalove M. EVALUATION OF THE SERUM GLUTAMIC OXALACETIC AMINOPHERASE (TRANSAMINASE) TESTITS USE IN DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION. JAMA. 1956;161(7):614–616. doi:10.1001/jama.1956.02970070046012
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