• Menopausal symptoms were treated by administering 6 mg. of methallenestril (a synthetic estrogen) daily to a test group of 100 women; a contratest group of 20 women received a placebo. Relief of symptoms was obtained in 91% of the test and 15% of the contratest group.
This subjective evidence was corroborated by the objective findings in vaginal smears taken from certain patients. An estrogenic response appeared after 10 to 14 days of this medication and persisted for 16 to 30 days after medication was stopped. The dosage used did not cause withdrawal bleeding or any other untoward effects but generally gave a feeling of well-being. A warning against unnecessarily prolonged medication is offered; periodic interruption to observe the results will determine whether additional therapy is required.
Goldfarb AF, Napp EE. USE OF METHALLENESTRIL (VALLESTRIL) IN CONTROL OF MENOPAUSAL SYMPTOMS. JAMA. 1956;161(7):616–618. doi:10.1001/jama.1956.02970070048013
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