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June 16, 1956


JAMA. 1956;161(7):644. doi:10.1001/jama.1956.02970070076026

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To the Editor:—  In their well-documented article on postanesthetic vomiting in The Journal, Feb. 4, 1956, page 376, Knapp and Beecher conclude that "at the present time it would probably be unwise to adopt therapy with... chlorpromazine, 50 mg., for routine use as prophylaxis against postoperative nausea, vomiting, and retching." This is a justifiable conclusion based on their scientific experiment in giving a generous standardized dose of the drug to 152 patients. Unfortunately, it is being interpreted by many readers as if it were an unfavorable report on the drug when used according to the principles of the art of medical practice. This it does not pretend to be. In the art of practice the physician selects the dose individually for each patient, alters his method if results are unfavorable, combines other drugs with it as indicated, and avoids them when they appear contraindicated. In using chlorpromazine in this latter

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