Some years ago, it was stated in these pages1 that "in the process of blood coagulation, thromboplastin acting on prothrombin in the presence of calcium forms thrombin, which in turn causes fibrinogen to change to fibrin."Essentially this concept is still accepted today. As it was thought then so it is today that there are certain factors that accelerate the process of blood coagulation. Many different names have been given to several of these factors that have been discovered in recent years. A good deal of confusion has been created as different investigators refer to one and the same substance by different names. In some instances it is not certain whether they do refer to the same substance. Some accept the existence of certain of these accelerators or activators of blood coagulation while others deny it. National and international bodies have now tried to bring some order
RESEARCH REVIEWS. JAMA. 1957;163(3):223–224. doi:10.1001/jama.1957.02970380065021
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