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There is considerable evidence that properly controlled low or moderate doses of androgen-estrogen combinations are of value in many of the common disorders that occur in elderly patients. Some of the symptoms that respond to such combined hormone therapy seem to be primarily psychogenic in nature, such as nervousness, irritability, forgetfulness, fatigue, and depression. Some of the symptoms are due to definite physical deficiencies. Postmenopausal osteoporosis frequently responds well to estrogen therapy, which stimulates osteoblastic activity. However, superior results are usually obtained with combined estrogen-androgen treatment. Retention of calcium and phosphorus in the bones is greater when androgens as well as estrogens are used. Androgens are especially effective in promoting storage of protein, which is required for formation of the bony matrix. Negative protein balance in elderly persons is often associated with negative calcium balance, not infrequently manifested by senile osteoporosis involving especially the spine. Protein storage is facilitated and
ANDROGEN-ESTROGEN THERAPY FOR ELDERLY PATIENTS. JAMA. 1957;163(5):359. doi:10.1001/jama.1957.02970400031012
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