• Pinworm infestation was treated in 100 patients by oral administration of promethazine. In each case the diagnosis was made by finding either the ova or the adult forms of Enterobius vermicularis. The patient was not required to fast before treatment but took a single bedtime dose of 125 mg. of promethazine hydrochloride.
Sleep was disturbed in only five instances. There was no drowsiness the following morning. Worms were detectable in the feces, but thereafter anal swabs showed absence of the parasites in all but three patients.
Patients in whom reinfection occurred 53 or more days after the first treatment were effectively treated a second time without difficulty. No indications of toxicity were found, and the advantages of an inexpensive, oral, one-dose treatment for pinworm infestation were evident.
Avery JL. TREATMENT OF ENTEROBIASIS WITH ONE ORAL DOSE OF PROMETHAZINE HYDROCHLORIDE. JAMA. 1956;161(8):681–683. doi:10.1001/jama.1956.02970080011004
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