• The growth of malignant tumors in the region of the nose and paranasal sinuses is insidious. The patient in whom symptoms occur early has a surprisingly good outlook, because vigorous combined surgical and radiologic treatment can be started early. Other patients may not have symptoms until the growth is far advanced. The microscopic classification of these tumors is unsatisfactory. The rapid advances of surgery, however, make it possible to operate much more effectively and safely than ever before, with a wide exposure and with due regard to the subsequent rehabilitation of the patient. Radiotherapeutic techniques have improved. Teletherapy permits homogeneous irradiation of large masses when that is desired. The use of molds for the central positioning of radium in cavities avoids the unevenness of irradiation ordinarily caused by the rapid fall-off in dose from contact radium. External radiation is used not only for inoperable lesions but also- as the sole method of therapy for patients who have lymphoma and lymphoepithelioma. The five-year survival rates for malignant tumors in this region, as reported by various contemporary groups, range from 10% to 23%.
Devine KD, Scanlon PW, Figi FA. MALIGNANT TUMORS OF THE NOSE AND PARANASAL SINUSES. JAMA. 1957;163(8):617–621. doi:10.1001/jama.1957.02970430007004
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