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February 23, 1957


JAMA. 1957;163(8):678. doi:10.1001/jama.1957.02970430068028

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To the Editor:—  Dr. B. W. Hiles, in the Correspondence section of the Dec. 29 issue of The Journal, page 1651, has presented observations of hyperglycemia and glycosuria in patients receiving chlorpromazine and has suggested the need for further investigation of these findings.I should like to call attention to a report by Charatan and Bartlett on this subject that appeared in the April, 1955, issue of The Journal of Mental Science, page 351, and an abstract of which appeared in the Sept. 10, 1955, issue of The Journal, page 144. The authors, on the basis of a report of a hyperglycemic effect in man treated with chlorpromazine, carried out a series of glucose tolerance tests on schizophrenics before and after a test dose of chlorpromazine. They considered the effect to be due to depression of liver function or stimulation of adrenal cortex by chlorpromazine.

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