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March 2, 1957


JAMA. 1957;163(9):797-798. doi:10.1001/jama.1957.02970440093033

SUPPRESSANTS OF ENDOCRINE FUNCTION  Research has led to the discovery of compounds that suppress certain endocrine functions.

Amphenone.—  Amphenone, or, chemically, 1,2-bis-( p-aminophenyl-2-methylpropanone-1, was synthesized in 1950.1 A study of the action of a wide variety of compounds related to diethylstilbestrol on the genital tract of oophorectomized female rats by R. Hertz and his colleagues,2 National Cancer Institute, Bethesda, Md., led to the testing of amphenone. At autopsy, the attention of these workers was attracted to the peculiar appearance of the adrenal glands. They were twice the normal size and had a peculiar discoloration quite different from the color noted in the adrenals of rats treated with estrogens or other substances. More complete autopsy studies showed that amphenone markedly inhibits adrenal and thyroid function. At present, it is the only nonsteroidal substance known that inhibits corticoid secretion by the adrenal cortex.Treatment with amphenone has been tried