• During the past 15 years, 553 patients who had carcinoma of the prostate were treated with castration, endocrines, or a combination of the two methods. The endocrines used were of the estrogen group. Immediate bilateral orchiectomy is advocated to eliminate the largest source of androgens. Experience indicates it might be best to withhold endocrine therapy from those patients with a low-grade carcinoma, without evidence of metastasis, and whose clinical course is satisfactory. This approach may add extra years of life for the patient. The benefits of adrenalectomy are so meager and of such short duration that further use of this procedure should be discouraged.
Ray EH. ENDOCRINE THERAPY OF PROSTATIC CARCINOMA. JAMA. 1957;163(12):1008–1010. doi:10.1001/jama.1957.02970470006002
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