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Article
March 23, 1957

ADRENALECTOMY FOR METASTATIC BREAST CARCINOMA

Author Affiliations

San Francisco

From the Cancer Research Institute, the Department of Surgery, and the Metabolic Unit, University of California School of Medicine.

JAMA. 1957;163(12):1011-1016. doi:10.1001/jama.1957.02970470009003
Abstract

• After oophorectomy the adrenal glands are the most significant remaining source of estrogens. Seventy-nine patients with advanced metastatic breast carcinoma underwent bilateral oophorectomy and adrenalectomy as a combination treatment-prophylaxis technique. There was no objective improvement in 38.7% of the patients and subjective improvement in 57.3%. Indications for this type of surgical management include objective demonstration of disseminated metastases. Jaundice from extensive liver metastases has been considered the only contraindication as far as location of the metastatic lesions are concerned.

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