• After oophorectomy the adrenal glands are the most significant remaining source of estrogens. Seventy-nine patients with advanced metastatic breast carcinoma underwent bilateral oophorectomy and adrenalectomy as a combination treatment-prophylaxis technique. There was no objective improvement in 38.7% of the patients and subjective improvement in 57.3%. Indications for this type of surgical management include objective demonstration of disseminated metastases. Jaundice from extensive liver metastases has been considered the only contraindication as far as location of the metastatic lesions are concerned.
Galante M, Fournier DJ, Wood DA. ADRENALECTOMY FOR METASTATIC BREAST CARCINOMA. JAMA. 1957;163(12):1011–1016. doi:10.1001/jama.1957.02970470009003
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