[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
March 23, 1957


Author Affiliations

San Francisco

From the Cancer Research Institute, the Department of Surgery, and the Metabolic Unit, University of California School of Medicine.

JAMA. 1957;163(12):1011-1016. doi:10.1001/jama.1957.02970470009003

• After oophorectomy the adrenal glands are the most significant remaining source of estrogens. Seventy-nine patients with advanced metastatic breast carcinoma underwent bilateral oophorectomy and adrenalectomy as a combination treatment-prophylaxis technique. There was no objective improvement in 38.7% of the patients and subjective improvement in 57.3%. Indications for this type of surgical management include objective demonstration of disseminated metastases. Jaundice from extensive liver metastases has been considered the only contraindication as far as location of the metastatic lesions are concerned.