• Cryoglobulinemia in the case here described lasted only a few weeks, and the intense peripheral plasmacytosis lasted only two or three days. The patient repeatedly developed well-defined wheals in response to five-second applications of ice cubes to the skin. This urticarial reaction was not obtained in normal subjects, and it was absent in this patient after a radical mastectomy was done to remove an adenocarcinoma. The cryoglobulinemia ceased at the same time. The evanescent character of these phenomena and their timing with respect to the development of tumors in this patient suggested that they might be interpreted as phases of an immune process in cancer.
Bohrod MG. PLASMACYTOSIS AND CRYOGLOBULINEMIA IN CANCER. JAMA. 1957;164(1):18–21. doi:10.1001/jama.1957.02980010020005
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