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Article
June 30, 1956

EFFECT OF RAUWOLFIA ALKALOIDS ON THE EXCRETION OF UROPEPSIN IN THE HUMAN

JAMA. 1956;161(9):864-865. doi:10.1001/jama.1956.62970090005017b
Abstract

In the number of observations on the pharmacology of Rauwolfia alkaloids, it is stated that increased intestinal peristalsis occurs rather frequently as a side-effect of these agents. In the dog, secretory and motor activity of the gastrointestinal tract is increased during administration of reserpine.1 On some occasions there is moderate heightening of colonic activity of the anesthetized rabbit or dog under the influence of reserpine, but, in these same experimental animals relaxation of the ileum has also been noted. In man, it is reported that diarrhea occurs often after administration of reserpine.2 Goodman and Gilman3 state that gastric secretion may be enhanced and that in all probability Rauwolfia and/or its derivatives is probably contraindicated in the treatment of ulcer until this aspect of the drug has been elucidated. The purpose of this report is to demonstrate the effects of Rauwolfia, if any, on gastric secretion, using the

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