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This is a study of the incidence of congenital syphilis among children whose mothers have histories of syphilis and of the relation of this incidence to the treatment of the mothers.
The histories of 1,279 children from 423 families were reviewed for this study. These families were selected on the basis that each included an infant, born late in 1950 or in 1951, who was followed by the Baltimore city health department in 1951 because of a history of syphilis in the mother. The records of 428 infants (there were five sets of twins), their siblings, and their mothers were reviewed. There were 59 children known to have been born before their mothers were infected, the mothers having had primary or secondary syphilis at the time of diagnosis, so that the approximate dates of their infections are known. These 59 children have been dropped from the study as
Nelson NA, Struve VR. PREVENTION OF CONGENITAL SYPHILIS BY TREATMENT OF SYPHILIS IN PREGNANCY. JAMA. 1956;161(9):869–872. doi:10.1001/jama.1956.62970090010017e
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