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May 11, 1957


JAMA. 1957;164(2):158-163. doi:10.1001/jama.1957.02980020038008

• In following the course of 10 patients with sarcoidosis through 16 pregnancies, it was observed that pregnancy appears to have an ameliorating effect on sarcoidosis during the prenatal period but that this benefit is frequently lost after delivery. All the patients tolerated pregnancy well; however, there were two abnormalities of pregnancy and three fetal abnormalities noted in the 16 pregnancies. The observed improvement of the sarcoidosis during pregnancy might constitute evidence against tuberculosis being the etiology of sarcoidosis, since pregnancy does not improve, and may even aggravate, tuberculosis. It is possible that improvement of sarcoidosis during pregnancy is due to the increase in production of corticoids by the adrenal glands during gestation.