• Viadril, a synthetic derivative of pregnanedione and succinic acid, was used as the primary anesthetic agent in 1,000 surgical operations. The customary premedication was given one hour before the induction. A total of 1 to 1.5 Gm. of Viadril was given intravenously, generally as a 0.5% solution in 5% dextrose and water, over a period of about four minutes. It took effect in about three minutes. The degree of anesthesia so produced was not sufficient for intubation and maintenance without the aid of muscle relaxants and inhalation anesthetics. There were no deaths attributable to the Viadril, but it had many unfavorable circulatory and respiratory effects. Its obtunding effect on laryngeal and pharyngeal reflexes, however, facilitated the insertion of an airway, and this suggests its utilization in surgery of the head and neck. It also indicates that further exploration of the anesthetic properties of other steroid compounds is desirable.
Ansbro FP, Blundell AE, Sweeney JC, Pillion JW. CLINICAL RESULTS WITH VIADRIL IN ONE THOUSAND CASES. JAMA. 1957;164(2):163–166. doi:10.1001/jama.1957.02980020043009
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