New aids have recently been reported in the differential diagnosis of the early stages of acute myocardial infarction when the electrocardiogram is inconclusive. It was shown by J. S. LaDue and F. Wróblewski,1 Memorial Center for Cancer and Allied Diseases, New York, that acute damage of the heart muscle cells associated with acute myocardial infarction is followed by the release of serum glutamic oxaloacetic transaminase. This has been confirmed by other workers,2 and various techniques for the measurement of this and other serum enzymes have been introduced.3That other enzymes present in heart muscle may behave similarly was suggested by the observation that the level of serum lactic dehydrogenase increases after acute myocardial infarction.4 Malic dehydrogenase, glucose isomerase, and serum aldolase levels are also raised.5The serum glutamic oxaloacetic transaminase level rises within 24 hours after acute myocardial infarction and falls
RESEARCH REVIEWS. JAMA. 1957;163(13):1201–1202. doi:10.1001/jama.1957.02970480105033
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