The importance of maintaining adequate nutrition in infections and other stress situations, particularly those of prolonged nature, has been appreciated increasingly in recent years. However, it is seldom possible to define adequate nutrition precisely, since knowledge of nutrient requirements in disease states is extremely meager. This is particularly true when vitamins are under consideration. The recent development of therapeutic preparations containing vitamins in combination with antibiotics focuses attention on this and allied problems, including the many complex relations between vitamin nutrition, infections, and antibiotics.1
That infections influence the requirement or utilization of certain vitamins in man is attested by the development of signs of vitamin deficiency during the course of many infections of long duration and by changes in the blood and tissue levels and urinary excretion of vitamins in these situations. Nevertheless, the exact requirement of particular vitamins in specific infections remains to be determined. The ingenuity of
Goldsmith GA. VITAMIN NUTRITION, INFECTIONS, AND ANTIBIOTICS: GUEST EDITORIAL. JAMA. 1956;161(9):882. doi:10.1001/jama.1956.02970090108018
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