• Although the exact mechanism is unknown, the administration of alphaprodine and possibly chlorpromazine can produce more satisfactory operating conditions when the patient is under light narcosis with thiopental. When the alphaprodine was administered, previously restless patients became quiet and stimulation of the skin and venipuncture no longer caused motion or withdrawal; at the same time, a decreased amount of thiopental was needed to produce the desired clinical response.
Mazzia VDB, Van Poznak A, Artusio JF. CORTICAL EFFECT OF ALPHAPRODINE AND OF CHLORPROMAZINE DURING THIOPENTAL NARCOSIS. JAMA. 1957;164(3):270–273. doi:10.1001/jama.1957.02980030046011
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