Biopsy of palpably enlarged peripheral lymph nodes has been used for many years to establish the nature and extent of intrathoracic lesions. In 1949, Daniels1 suggested that biopsy of deep, nonpalpable lymph nodes of the lower neck and upper mediastinum be performed to diagnose such lesions when there is no palpable supraclavicular node enlargement. He reported five instances in which this technique yielded a diagnosis not obtainable by any other method than that of exploratory thoracotomy. Further reports of the successful use of this technique of prescalene lymph node biopsy were made by Weiss and co-workers,2 Johnson and MacCurdy,3 and Storey and Reynolds.4 Evaluations of prescalene node biopsy in larger series of patients were later reported by Shefts and co-workers,5 Cuykendall,6 Harken and co-workers,7 and Connar.8
Intrathoracic lesions in which examination of the prescalene lymph nodes has yielded a positive diagnosis include
Felton WL, Spear HC. CERVICAL MEDIASTINAL LYMPH NODE BIOPSY IN EVALUATING INTRATHORACIC DISEASE. JAMA. 1957;163(14):1252–1254. doi:10.1001/jama.1957.82970490001011
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