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Article
April 13, 1957

USE OF HYALURONIDASE TO REDUCE EDEMA IN SEVERE COMPOUND FRACTURE OF AN EXTREMITYCLINICAL REPORT

JAMA. 1957;163(15):1358. doi:10.1001/jama.1957.82970500002011a

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Abstract

The following case of severe compound fracture is reported to illustrate the use of hyaluronidase in reducing operative and traumatic edema and hemorrhage.

Report of a Case  On Feb. 11, 1956, a 21-year-old airman was involved in a motorcycle accident. He sustained, in addition to multiple minor injuries, a major injury to the right lower extremity, this injury consisting of a transverse fracture of the tibia and fibula at the junction of the middle and lower one-third. The fracture was badly compounded, and there was considerable foreign matter in the superficial parts of the wound. The distal portion of the extremity was markedly distorted by edema and hemorrhage. There was no dorsalis pedis pulse.The patient was prepared for immediate reduction of the fracture, wound débridement, and restoration of the blood supply to the distal portion of the extremity. With the patient under general anesthesia, a curvilinear incision was made

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