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June 30, 1956


JAMA. 1956;161(9):901-902. doi:10.1001/jama.1956.02970090127027

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To the Editor:—  In the guest editorial "Allergy to Penicillin," by S. A. Feinberg and A. R. Feinberg (J. A. M. A.160:778 [March 3] 1956), an erroneous statement appeared, in my opinion. According to Feinberg and Feinberg the "two most important allergic reactions from penicillin are the delayed, serum-sickness type and the immediate, anaphylactic variety." Allergic reactions fall into two main categories: the immediate and the delayed responses. Serum-sickness is one of the most representative entities of the immediate (anaphylactic) type. Clemens von Pirquet and Bela Schick stated this in their classic monograph "Die Serumkrankheit" as early as 1905, and extensive clinical and experimental researches since then have corroborated their theories in every respect. Regarding the classification of the allergic responses, I may perhaps refer to S. Raffel (Immunity, Hypersensitivity, Serology, New York, Appleton-Century-Crofts, Inc., 1953, pp. 199-200), who states:"When one surveys the variety of hypersensitive manifestations

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