• The lipemia following ingestion of fat was studied in 15 healthy subjects and 4 patients with pancreatic insufficiency. In addition to serum turbidity measurements and chylomicron counts, chemical methods were used to obtain values for total lipid, neutral fat, cholesterol, and phospholipid. In healthy subjects the ingestion of 1 Gm. of fat per kilogram of body weight gave satisfactory rises in serum turbidity, total lipid, and neutral fat, while 0.5 Gm. per kilogram sufficed to give rises in turbidity and chylomicron counts. The 0.5 Gm. per kilogram dose given to the patients with pancreatic insufficiency was not followed by consistent or significant rises in turbidity, chylomicron count, or total lipid. Serial determinations of serum turbidity after administration of fat therefore appeared to offer a simple method of following fat absorption and utilization and to constitute a clinical test applicable to various gastrointestinal and metabolic diseases.
Osmon KL, Zinn WJ, Wharton GK. SIMPLIFIED TEST OF FAT ABSORPTION: COMPARISON OF SERUM TURBIDITY, CHYLOMICRONEMIA, AND TOTAL LIPID VALUES AFTER FAT TEST MEAL. JAMA. 1957;164(6):633–638. doi:10.1001/jama.1957.02980060009003
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: