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Article
April 27, 1957

GASTRIC RESPONSE TO FROZEN ORANGE JUICE AND BETAZOLE HYDROCHLORIDE (HISTALOG)

JAMA. 1957;163(17):1602-1603. doi:10.1001/jama.1957.82970520001012
Abstract

The ingestion of orange juice by patients with peptic ulcers has been the subject of discussion for several years. Some patients with ulcers complain that orange juice causes epigastric distress. If true, the mechanism by which this occurs is not clear. It is generally accepted that the relief of pain and the facilitation of healing of the ulcer are accomplished by the control of gastric acidity. A factor of equal importance, however, is the nutritional state of the cells of the mucosa, which must withstand the eroding effect of the acid. The resistance of these cells may be adversely affected by caloric deficiencies resulting from starvation, vitamin deficiencies as exemplified by scurvy and purpuras, and acute and chronic infections. A comprehensive regimen for the management of patients with peptic ulcer must include adequate diet, administration of antacids and anticholingerics, rest, sedation, and the management of psychosomatic and emotional factors.

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