• A total of 16 cases of primary aldosteronism have been reported in the literature. Twelve of the patients have been cured: 10 by the removal of an adrenocortical adenoma, one by total adrenalectomy, and one by subtotal adrenalectomy. In three cases, reported in detail, the sodium-retaining substance was identified as aldosterone diacetate and was present in large amounts in the urine. There appears to be a distinct entity, with typical clinical, biochemical, and renal findings, that should lead the physician to suspect the presence of primary aldosteronism.
Hewlett JS, McCullagh EP, Farrell GL, Dustan HP, Poutasse EF, Proudfit WL. ALDOSTERONE-PRODUCING TUMORS OF THE ADRENAL GLAND: REPORT OF THREE CASES. JAMA. 1957;164(7):719–726. doi:10.1001/jama.1957.02980070001001
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