The increasing frequency with which cases of Kartagener's syndrome (situs inversus, bronchiectasis, and sinusitis) have been recorded in the literature in recent years signifies a heightened awareness of a challenging, complex clinical entity. An editorial1 in The Journal on this topic in 1953 referred to 41 cases described in the literature, whereas, in one of the latest reports, Taiana and co-workers2 found a total of 104 cases.
Aside from the well-established clinical features of this disease, consideration of its pathogenesis with respect to bronchiectasis, whether on a congenital or acquired basis, has provided many authors with a fertile field of speculation. As interesting and provocative as the genetic aspects of this condition may be, they are nevertheless overshadowed by the role of the overt respiratory symptoms. Their frequent occurrence during the early years of life in most of the reported cases of Kartagener's syndrome entails their paramount consideration
Nichamin SJ. KARTAGENER'S SYNDROME IN A NEWBORN INFANT. JAMA. 1956;161(10):966–968. doi:10.1001/jama.1956.62970100004009b
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