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June 22, 1957


JAMA. 1957;164(8):914-915. doi:10.1001/jama.1957.02980080084020

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To the Editor:—  One essential condition of the study was to determine, if possible, the effect on the skin of the detergent or soap product alone. We attempted to reduce the patients' cutaneous exposure factor to 1 by removing them from their household or occupational milieu and hospitalizing them for two to three weeks, during which time the detergent or soap solutions were essentially the only materials to which their hands were exposed.During the first week of the test one hand was immersed for 30 minutes twice daily in 0.5% solution of a synthetic detergent washing product at 105 F and during the second week in the same concentration of the soap washing product. The sequence of these immersions was alternated in each subject. The control hand was immersed in tap water at 105 F for the same period as the test exposure. The tests were carried out both

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