• Propoxyphene is a new synthetic analgesic with the effectiveness of codeine but having less undesirable gastrointestinal side-effects when administered in 65-mg. dosage. Many of the side-effects that were reported were comparable to those elicited by placebo. Over a two-year period no patients have shown a desire for, or need of, an increased dosage of the drug, nor was any true idiosyncrasy seen.
Gruber CM. CODEINE PHOSPHATE, PROPOXYPHENE HYDROCHLORIDE, AND PLACEBO. JAMA. 1957;164(9):966–969. doi:10.1001/jama.1957.02980090020006
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