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Article
July 13, 1957

CLINICAL SPECTRUM OF ERYTHROMYCIN AS EVALUATED IN TWO HUNDRED SIXTY PATIENTS

JAMA. 1957;164(11):1197-1204. doi:10.1001/jama.1957.02980110023005
Abstract

• Erythromycin was administered orally and parenterally in 260 cases of bacterial infections of various types. The largest groups of patients were those with pneumonia caused by Diplococcus pneumoniae (213), meningitis caused by D. pneumoniae (7), micrococcic infections (10), gonococcic infections (6), and streptococcic infections (6). It was found possible to give dosages as high as 8 Gm. per day and to achieve blood concentrations up to 20 mcg. per milliliter or more, with only occasional minimal side-effects. Results were good in 199 of the 213 patients with pneumococcic pneumonia, and excellent in 2 of the 7 patients with fulminating pneumococcic meningitis and in 2 of 3 patients with meningococcic meningitis. Results were excellent in four out of five patients with infections caused by group A beta-hemolytic streptococci (including one case of endocarditis). The results in general demonstrated the effectiveness of erythromycin in a wide variety of mild and severe infections and broadened the scope of usefulness of this agent.

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