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July 7, 1956

The Relationship Between Syringomyelia and Neoplasm

JAMA. 1956;161(10):1030. doi:10.1001/jama.1956.02970100096031

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The author reviews in some detail 234 autopsies in which syringomyelia was found to be associated with neoplasia of the central nervous system. A brief review of the theories of pathogenesis is presented as well as a discussion of the incidence of these conditions. The presentation is amply supplemented with analytic tables and graphs, though a few of these seem a trifle rich in data, thus partially obviating their usefulness. On analysis it was found that the majority of the histological types of tumors in this group fell into a class the author and others considered to be congenital in origin. The author believes that this material suggests that neoplasia and syrinx formation are the result of faulty differentiation associated with the closure of the neural tube. An alphabetical list of all the cases is presented together with an exhaustive bibliography that should make this monograph a useful reference source.

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