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Article
July 27, 1957

GASTRIC ACIDITY DETERMINATION PROCEDURES: COMPARISON OF A TUBELESS METHOD WITH AZURE A RESIN COMPOUND AND AN INTUBATION METHOD WITH HISTAMINE

Author Affiliations

New York

From the Division of Gastroenterology, Department of Medicine, and Department of Surgery, Beth Israel Hospital, New York.

JAMA. 1957;164(13):1467-1468. doi:10.1001/jama.1957.62980130003010a
Abstract

The purpose of this report is to present a comparison of findings on gastric secretion when a tubeless method with azure A resin compound (Diagnex Improved) and an intubation method with histamine stimulation are both employed in the same patient.

In 1950. Segal, Miller, and Morton1 described a method for determining the presence or absence of free hydrochloric acid in the stomach without the use of intubation. This procedure consisted of the oral administration of an ion-exchange resin coupled with quinine. Although this technique was reliable,2 it was not widely adopted because of the complicated laboratory facilities necessary in analyzing the quinine compound excreted in the urine.

The subsequent development of a stable carboxylic resin indicator with azure A for the detection of free gastric hydrochloric acid3 has provided a method that has proved to be simple and practical. This determination involves a displacement of the azure

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