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July 27, 1957


Author Affiliations

20 Fifth Ave. New York 11.

JAMA. 1957;164(13):1504-1505. doi:10.1001/jama.1957.02980130080022

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To the Editor:—  It has been two years since the introduction of tolbutamide (Orinase) in the United States. Many of us have had excellent results from its use. All observers agree that it is effective in the obese, elderly patient with mild diabetes and that it is a valuable contribution in the treatment of diabetes mellitus, points which were well covered in the excellent editorial that appeared in the June 1, 1957, issue of The Journal. However, I feel that a completely incorrect impression that the orally given hypoglycemic agents are insulin substitutes is created by such articles as "Clinical Use of Tolbutamide (Orinase) in Office and Home Care of Diabetics" in the June 8, 1957, issue of The Journal. I must express my objection especially to the statement, "No longer do their [diabetics'] lives depend upon a refrigerator's proximity—a liberation of marked psychological importance." Furthermore, 45 cases is a

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