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August 17, 1957


Author Affiliations

129 Eighth Ave. Brooklyn, N. Y.

JAMA. 1957;164(16):1842. doi:10.1001/jama.1957.02980160114017

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To the Editor:—  The notes of caution in the editorial in the June 1, 1957, issue of The Journal on the use of tolbutamide (Orinase) in the treatment of the diabetic are commendable. I feel, however, that there are certain aspects of the subject which should receive more consideration.It seems to me that the problem of seeking oral substitutes for insulin has pointed up the important question of what it is we aim to accomplish in treating the diabetic. The philosophical concepts which arose from the contributions of the early investigators in the field such as Rubner, Voit, Lusk, and Dubois would appear to indicate that this common and remarkable disease is primarily the result of a defect in the utilization of the dextrose molecule by the human organism. What should, therefore, be the aim in therapy but to seek those measures which would correct this metabolic derangement and

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