• In order to determine the extent of local and general reactions after immunization to tetanus and diphtheria, 2,974 university students were reexamined 48 hours after the first dose. The tetanus toxoid (alum-precipitated) was given in doses of 0.5 cc. intramuscularly to those students who had reacted negatively in the Shick test; those who had reacted positively to the Shick test received intramuscularly 0.5 cc. of alum-precipitated combined diphtheria and tetanus toxoid. Both local and general reactions were more frequent in women than in men. For the group as a whole, 70.4% of those receiving tetanus toxoid were found to have local reactions as compared with 51.7% of those receiving the combined tetanusdiphtheria toxoid; general reactions, however, were significantly more frequent after the combined tetanus-diphtheria toxoid than after the tetanus toxoid. The reactions are not severe enough to militate against the routine use of these vaccines in students entering college.
Boynton RE, Cowan DW, Rupprecht P. IMMUNIZATION OF COLLEGE STUDENTS AGAINST DIPHTHERIA. JAMA. 1957;164(17):1874–1879. doi:10.1001/jama.1957.02980170014003
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